Save 25% off online orders thru 11/14! Promo code: VETS 2019

Glucose absorption from starch hydrolysates in the human jejunum.

June 30, 2014

 1983 Dec;24(12):1152-60.

Glucose absorption from starch hydrolysates in the human jejunum.

Abstract

The intestinal absorption and mucosal hydrolysis of a partial and a complete alpha-amylase hydrolysate of corn starch, simulating the normal intermediary and end products of luminal starch digestion, was studied using an in vivo steady state jejunal perfusion technique in normal human subjects. Alpha-amylase was excluded from the test segment by proximal balloon occlusion. Products of hydrolysis during intestinal perfusion were identified using gel permeation chromatography. Three isocaloric, isotonic sugar saline solutions containing 140 mM glucose, 70 mM maltose and the partial amylase hydrolysate of starch (51.5 +/- 1.4% of glucose content comprising glucose polymers of more than 10 glucose units) were perfused in the first study. Net glucose absorption during perfusion of the partial hydrolysate and free glucose was similar, but significantly faster from maltose (p less than 0.05). Hydrolysis of the polymer fraction containing more than 10 glucose units was significantly slower (29.5 +/- 2.0% of infused load) than the lower molecular weight fraction (56.4 +/- 3.8%, p less than 0.001). As net glucose absorption from the partial hydrolysate was similar to that from glucose, despite the slow hydrolysis of the higher molecular weight fraction, it seemed likely that oligosaccharides in the more rapidly hydrolysed lower molecular weight fractions were exerting a kinetic advantage on glucose absorption. This was confirmed in a second study, where glucose absorption from a complete amylase hydrolysate consisting predominantly of maltose, maltotriose and alpha-limit dextrins, occurred significantly faster (81.8 +/- 4.8 mmol/h/25 cm) than from isocaloric free glucose (55.8 +/- 4.9 mmol/h/25 cm, p less than 0.001). Chromatograms of intestinal aspirates suggested that (1->4), but not 1->6) linked oligosaccharides liberated during luminal and brush-border hydrolysis of dietary starch conferred a kinetic advantage on glucose absorption.

PMID:
 
6605901
 
[PubMed - indexed for MEDLINE] 
PMCID:
 
PMC1420254
 
Free PMC Article




Leave a comment

Comments will be approved before showing up.


Also in The CeraSport Blog

Cera Products, Established in 1993, Serving the Military since 1999
Cera Products, Established in 1993, Serving the Military since 1999

November 08, 2019

View full article →

Sports Drinks: Back to Basics
Sports Drinks: Back to Basics

August 29, 2019

 

It's that time of year: SCHOOL TIME!  Don't leave the learning to the kids, get Back to the Basics with your sports drink knowledge.  

View full article →

Treating the Dreaded Hangover
Treating the Dreaded Hangover

May 23, 2019

Understanding the causes of your hangover and how Cerasport EX1 is the perfect way to treat it.

View full article →